New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase

[Image: see text] Deoxyhypusine synthase (DHPS) is the primary enzyme responsible for the hypusine modification and, thereby, activation of the eukaryotic translation initiation factor 5A (eIF5A), which is key in regulating the protein translation processes associated with tumor proliferation. Altho...

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Detalles Bibliográficos
Autores principales: Tanaka, Yuta, Kurasawa, Osamu, Yokota, Akihiro, Klein, Michael G., Saito, Bunnai, Matsumoto, Shigemitsu, Okaniwa, Masanori, Ambrus-Aikelin, Geza, Uchiyama, Noriko, Morishita, Daisuke, Kimura, Hiromichi, Imamura, Shinichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323115/
https://www.ncbi.nlm.nih.gov/pubmed/34345355
http://dx.doi.org/10.1021/acsmedchemlett.0c00331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323115/
https://www.ncbi.nlm.nih.gov/pubmed/34345355
http://dx.doi.org/10.1021/acsmedchemlett.0c00331

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