Rac1/ROCK-driven membrane dynamics promote natural killer cell cytotoxicity via granzyme-induced necroptosis

BACKGROUND: Natural killer (NK) cells play an important role in cancer immunosurveillance and therapy. However, the target selectivity of NK cell activity is still poorly understood. RESULTS: Here, we used live-cell reporters to unravel differential epithelial cancer target killing by primary human...

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Detalles Bibliográficos
Autores principales: Zhu, Yanting, Xie, Jun, Shi, Jue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323222/
https://www.ncbi.nlm.nih.gov/pubmed/34325694
http://dx.doi.org/10.1186/s12915-021-01068-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323222/
https://www.ncbi.nlm.nih.gov/pubmed/34325694
http://dx.doi.org/10.1186/s12915-021-01068-3

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