Activation of microglial GLP-1R in the trigeminal nucleus caudalis suppresses central sensitization of chronic migraine after recurrent nitroglycerin stimulation

BACKGROUND: Central sensitization is considered a critical pathogenic mechanism of chronic migraine (CM). Activation of microglia in the trigeminal nucleus caudalis (TNC) contributes to this progression. Microglial glucagon-like peptide-1 receptor (GLP-1R) activation can alleviate pain; however, whe...

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Detalles Bibliográficos
Autores principales: Jing, Feng, Zou, Qian, Wang, Yangyang, Cai, Zhiyou, Tang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323319/
https://www.ncbi.nlm.nih.gov/pubmed/34325647
http://dx.doi.org/10.1186/s10194-021-01302-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323319/
https://www.ncbi.nlm.nih.gov/pubmed/34325647
http://dx.doi.org/10.1186/s10194-021-01302-x

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