Tryptophan potentiates CD8(+) T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation

BACKGROUND: Tryptophan catabolites suppress immunity. Therefore, blocking tryptophan catabolism with indoleamine 2,3-dioxygenase (IDO) inhibitors is pursued as an anticancer strategy. METHODS: The intracellular level of tryptophan and kynurenine was detected by mass spectrum analysis. The effect of...

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Detalles Bibliográficos
Autores principales: Qin, Rui, Zhao, Chen, Wang, Chen-Ji, Xu, Wei, Zhao, Jian-Yuan, Lin, Yan, Yuan, Yi-Yuan, Lin, Peng-Cheng, Li, Yao, Zhao, Shimin, Huang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323461/
https://www.ncbi.nlm.nih.gov/pubmed/34326168
http://dx.doi.org/10.1136/jitc-2021-002840

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323461/
https://www.ncbi.nlm.nih.gov/pubmed/34326168
http://dx.doi.org/10.1136/jitc-2021-002840

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