PlzA is a bifunctional c-di-GMP biosensor that promotes tick and mammalian host-adaptation of Borrelia burgdorferi

In this study, we examined the relationship between c-di-GMP and its only known effector protein, PlzA, in Borrelia burgdorferi during the arthropod and mammalian phases of the enzootic cycle. Using a B. burgdorferi strain expressing a plzA point mutant (plzA-R145D) unable to bind c-di-GMP, we confi...

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Detalles Bibliográficos
Autores principales: Groshong, Ashley M., Grassmann, André A., Luthra, Amit, McLain, Melissa A., Provatas, Anthony A., Radolf, Justin D., Caimano, Melissa J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323883/
https://www.ncbi.nlm.nih.gov/pubmed/34265024
http://dx.doi.org/10.1371/journal.ppat.1009725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8323883/
https://www.ncbi.nlm.nih.gov/pubmed/34265024
http://dx.doi.org/10.1371/journal.ppat.1009725

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