Role of BRCA2 DNA-binding and C-terminal domain in its mobility and conformation in DNA repair

Breast cancer type two susceptibility protein (BRCA2) is an essential protein in genome maintenance, homologous recombination (HR), and replication fork protection. Its function includes multiple interaction partners and requires timely localization to relevant sites in the nucleus. We investigated...

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Detalles Bibliográficos
Autores principales: Paul, Maarten W, Sidhu, Arshdeep, Liang, Yongxin, van Rossum-Fikkert, Sarah E, Odijk, Hanny, Zelensky, Alex N, Kanaar, Roland, Wyman, Claire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324294/
https://www.ncbi.nlm.nih.gov/pubmed/34254584
http://dx.doi.org/10.7554/eLife.67926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324294/
https://www.ncbi.nlm.nih.gov/pubmed/34254584
http://dx.doi.org/10.7554/eLife.67926

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