Structurally distributed surface sites tune allosteric regulation

Our ability to rationally optimize allosteric regulation is limited by incomplete knowledge of the mutations that tune allostery. Are these mutations few or abundant, structurally localized or distributed? To examine this, we conducted saturation mutagenesis of a synthetic allosteric switch in which...

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Detalles Bibliográficos
Autores principales: McCormick, James W, Russo, Marielle AX, Thompson, Samuel, Blevins, Aubrie, Reynolds, Kimberly A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Evolutionary Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324303/
https://www.ncbi.nlm.nih.gov/pubmed/34132193
http://dx.doi.org/10.7554/eLife.68346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324303/
https://www.ncbi.nlm.nih.gov/pubmed/34132193
http://dx.doi.org/10.7554/eLife.68346

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