Asxl1 C-terminal mutation perturbs neutrophil differentiation in zebrafish

ASXL1 is one of the most frequently mutated genes in malignant myeloid diseases. In patients with myeloid malignancies, ASXL1 mutations are usually heterozygous frameshift or nonsense mutations leading to C-terminal truncation. Current disease models have predominantly total loss of ASXL1 or overexp...

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Detalles Bibliográficos
Autores principales: Fang, Xiao, Xu, Song’en, Zhang, Yiyue, Xu, Jin, Huang, Zhibin, Liu, Wei, Wang, Shunqing, Yen, Kuangyu, Zhang, Wenqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324474/
https://www.ncbi.nlm.nih.gov/pubmed/33483612
http://dx.doi.org/10.1038/s41375-021-01121-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324474/
https://www.ncbi.nlm.nih.gov/pubmed/33483612
http://dx.doi.org/10.1038/s41375-021-01121-8

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