Base editing-coupled survival screening enabled high-sensitive analysis of PAM compatibility and finding of the new possible off-target

Base editing (BE) is a promising genome engineering tool for modifying DNA or RNA and has been widely used in various microorganisms as well as eukaryotic cells. Despite the proximal protospacer adjacent motif (PAM) is critical to the targeting range and off-target effect of BE, there is still lack...

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Detalles Bibliográficos
Autores principales: Su, Tianyuan, Guo, Qi, Zheng, Yi, Chang, Yizhao, Gu, Fei, Lu, Xuemei, Qi, Qingsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324807/
https://www.ncbi.nlm.nih.gov/pubmed/34337358
http://dx.doi.org/10.1016/j.isci.2021.102769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324807/
https://www.ncbi.nlm.nih.gov/pubmed/34337358
http://dx.doi.org/10.1016/j.isci.2021.102769

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