Endo-lysosomal Aβ concentration and pH trigger formation of Aβ oligomers that potently induce Tau missorting

Amyloid-β peptide (Aβ) forms metastable oligomers >50 kDa, termed AβOs, that are more effective than Aβ amyloid fibrils at triggering Alzheimer’s disease-related processes such as synaptic dysfunction and Tau pathology, including Tau mislocalization. In neurons, Aβ accumulates in endo-lysosomal v...

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Detalles Bibliográficos
Autores principales: Schützmann, Marie P., Hasecke, Filip, Bachmann, Sarah, Zielinski, Mara, Hänsch, Sebastian, Schröder, Gunnar F., Zempel, Hans, Hoyer, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324842/
https://www.ncbi.nlm.nih.gov/pubmed/34330900
http://dx.doi.org/10.1038/s41467-021-24900-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324842/
https://www.ncbi.nlm.nih.gov/pubmed/34330900
http://dx.doi.org/10.1038/s41467-021-24900-4

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