Prolonged norovirus infections correlate to quasispecies evolution resulting in structural changes of surface-exposed epitopes

In this study, we analyzed norovirus (NoV) evolution in sequential samples of six chronically infected patients. The capsid gene was amplified from stool samples, and deep sequencing was performed. The role of amino acid flexibility in structural changes and ligand binding was studied with molecular...

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Detalles Bibliográficos
Autores principales: Afridi, Suliman Qadir, Usman, Zainab, Donakonda, Sainitin, Wettengel, Jochen Martin, Velkov, Stoyan, Beck, Robert, Gerhard, Markus, Knolle, Percy, Frishman, Dmitrij, Protzer, Ulrike, Moeini, Hassan, Hoffmann, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324856/
https://www.ncbi.nlm.nih.gov/pubmed/34355146
http://dx.doi.org/10.1016/j.isci.2021.102802

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8324856/
https://www.ncbi.nlm.nih.gov/pubmed/34355146
http://dx.doi.org/10.1016/j.isci.2021.102802

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