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Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics: Getting the message across
The recent approval of messenger RNA (mRNA)-based vaccines to combat the SARS-CoV-2 pandemic highlights the potential of both conventional mRNA and self-amplifying mRNA (saRNA) as a flexible immunotherapy platform to treat infectious diseases. Besides the antigen it encodes, mRNA itself has an immun...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325057/ https://www.ncbi.nlm.nih.gov/pubmed/34324884 http://dx.doi.org/10.1016/j.addr.2021.113900 |