ecRESCUE: a novel ecDHFR-regulated RESCUE system with reduced RNA off-targeting activity

The currently available RESCUE RNA base editing system demonstrates considerable potential for the treatment of genetic diseases at the transcriptional level. However, the relatively high incidence of off-target events hampers the precise RNA editing, thereby limiting its use in the clinical setting...

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Detalles Bibliográficos
Autores principales: Wang, Yihan, Li, Guo, Li, Xiangyang, Wang, Yuzhe, Huang, Xingxu, Hu, Xiaoxiang, Gao, Jianen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325194/
https://www.ncbi.nlm.nih.gov/pubmed/34332602
http://dx.doi.org/10.1186/s12964-021-00759-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325194/
https://www.ncbi.nlm.nih.gov/pubmed/34332602
http://dx.doi.org/10.1186/s12964-021-00759-2

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