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ecRESCUE: a novel ecDHFR-regulated RESCUE system with reduced RNA off-targeting activity
The currently available RESCUE RNA base editing system demonstrates considerable potential for the treatment of genetic diseases at the transcriptional level. However, the relatively high incidence of off-target events hampers the precise RNA editing, thereby limiting its use in the clinical setting...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325194/ https://www.ncbi.nlm.nih.gov/pubmed/34332602 http://dx.doi.org/10.1186/s12964-021-00759-2 |