Dynamic chromatin regulatory landscape of human CAR T cell exhaustion

Dysfunction in T cells limits the efficacy of cancer immunotherapy. We profiled the epigenome, transcriptome, and enhancer connectome of exhaustion-prone GD2-targeting HA-28z chimeric antigen receptor (CAR) T cells and control CD19-targeting CAR T cells, which present less exhaustion-inducing tonic...

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Detalles Bibliográficos
Autores principales: Gennert, David G., Lynn, Rachel C., Granja, Jeff M., Weber, Evan W., Mumbach, Maxwell R., Zhao, Yang, Duren, Zhana, Sotillo, Elena, Greenleaf, William J., Wong, Wing H., Satpathy, Ansuman T., Mackall, Crystal L., Chang, Howard Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325267/
https://www.ncbi.nlm.nih.gov/pubmed/34285077
http://dx.doi.org/10.1073/pnas.2104758118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325267/
https://www.ncbi.nlm.nih.gov/pubmed/34285077
http://dx.doi.org/10.1073/pnas.2104758118

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