Pharmacokinetic/pharmacodynamic investigation of raltegravir with or without lamivudine in the context of HIV-1 pre-exposure prophylaxis (PrEP)

BACKGROUND: To characterize their potential use in pre-exposure prophylaxis (PrEP) we compared the pharmacokinetics of raltegravir and lamivudine in genital tissue against ex vivo tissue infection with HIV-1. METHODS: Open-label trial of 36 HIV-negative females and males randomized to 7 days raltegr...

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Detalles Bibliográficos
Autores principales: Herrera, Carolina, Lwanga, Julianne, Lee, Ming, Mantori, Suna, Amara, Alieu, Else, Laura, Penchala, Sujan Dilly, Egan, Deirdre, Challenger, Elizabeth, Dickinson, Laura, Boffito, Marta, Shattock, Robin, Khoo, Saye, Fox, Julie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325523/
https://www.ncbi.nlm.nih.gov/pubmed/33993302
http://dx.doi.org/10.1093/jac/dkab136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325523/
https://www.ncbi.nlm.nih.gov/pubmed/33993302
http://dx.doi.org/10.1093/jac/dkab136

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