Mechanisms of disease-modifying effect of saracatinib (AZD0530), a Src/Fyn tyrosine kinase inhibitor, in the rat kainate model of temporal lobe epilepsy

We have recently demonstrated the role of the Fyn-PKCδ signaling pathway in status epilepticus (SE)-induced neuroinflammation and epileptogenesis in experimental models of temporal lobe epilepsy (TLE). In this study, we show a significant disease-modifying effect and the mechanisms of a Fyn/Src tyro...

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Detalles Bibliográficos
Autores principales: Sharma, Shaunik, Carlson, Steven, Gregory-Flores, Adriana, Hinojo-Perez, Andy, Olson, Ashley, Thippeswamy, Thimmasettappa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325782/
https://www.ncbi.nlm.nih.gov/pubmed/34087381
http://dx.doi.org/10.1016/j.nbd.2021.105410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325782/
https://www.ncbi.nlm.nih.gov/pubmed/34087381
http://dx.doi.org/10.1016/j.nbd.2021.105410

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