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Crystal structure of the MyRF ICA domain with its upstream β-helical stalk reveals the molecular mechanisms underlying its trimerization and self-cleavage
Myelin gene regulatory factor (MyRF), a novel membrane transcription factor expressed on the endoplasmic reticulum membrane, functions as a trimer. The trimerization of MyRF is associated with a fragment between the DNA binding domain and transmembrane domain that shares homology with the triple-β-h...
Autores principales: | Wu, Pei, Zhen, Xiangkai, Li, Bowen, Yu, Qian, Huang, Xiaochen, Shi, Ning |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326128/ https://www.ncbi.nlm.nih.gov/pubmed/34345217 http://dx.doi.org/10.7150/ijbs.57673 |
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