Intercellular cGAMP transmission induces innate immune activation and tissue inflammation in Trex1 deficiency

Intercellular transmission of the second messenger 2′,3′-cGAMP, synthesized by the viral DNA sensor cGAMP synthase (cGAS), is a potent mode of bystander activation during host defense. However, whether this mechanism also contributes to cGAS-dependent autoimmunity remains unknown. Here, using a muri...

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Detalles Bibliográficos
Autores principales: Jütte, Bianca B., Krollmann, Calvin, Cieslak, Kevin, Koerber, Ruth-Miriam, Boor, Peter, Graef, Claus M., Bartok, Eva, Wagner, Mirko, Carell, Thomas, Landsberg, Jennifer, Aymans, Pia, Wenzel, Jörg, Brossart, Peter, Teichmann, Lino L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326191/
https://www.ncbi.nlm.nih.gov/pubmed/34368651
http://dx.doi.org/10.1016/j.isci.2021.102833

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326191/
https://www.ncbi.nlm.nih.gov/pubmed/34368651
http://dx.doi.org/10.1016/j.isci.2021.102833

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