Targeting ITK signaling for T cell-mediated diseases

The focus of this review is to examine the role of ITK signaling in multiple diseases and investigate the clinical potential of ITK inhibition. The diseases and potential interventions reviewed include T cell-derived malignancies as well as other neoplastic diseases, allergic diseases such as asthma...

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Detalles Bibliográficos
Autores principales: Weeks, Samuel, Harris, Rebecca, Karimi, Mobin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326193/
https://www.ncbi.nlm.nih.gov/pubmed/34368657
http://dx.doi.org/10.1016/j.isci.2021.102842
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author Weeks, Samuel
Harris, Rebecca
Karimi, Mobin
author_facet Weeks, Samuel
Harris, Rebecca
Karimi, Mobin
author_sort Weeks, Samuel
collection PubMed
description The focus of this review is to examine the role of ITK signaling in multiple diseases and investigate the clinical potential of ITK inhibition. The diseases and potential interventions reviewed include T cell-derived malignancies as well as other neoplastic diseases, allergic diseases such as asthma and atopic dermatitis, certain infectious diseases, several autoimmune disorders such as rheumatoid arthritis and psoriasis, and finally the use of ITK inhibition in both solid organ and bone marrow transplantation recipients.
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spelling pubmed-83261932021-08-06 Targeting ITK signaling for T cell-mediated diseases Weeks, Samuel Harris, Rebecca Karimi, Mobin iScience Review The focus of this review is to examine the role of ITK signaling in multiple diseases and investigate the clinical potential of ITK inhibition. The diseases and potential interventions reviewed include T cell-derived malignancies as well as other neoplastic diseases, allergic diseases such as asthma and atopic dermatitis, certain infectious diseases, several autoimmune disorders such as rheumatoid arthritis and psoriasis, and finally the use of ITK inhibition in both solid organ and bone marrow transplantation recipients. Elsevier 2021-07-14 /pmc/articles/PMC8326193/ /pubmed/34368657 http://dx.doi.org/10.1016/j.isci.2021.102842 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Weeks, Samuel
Harris, Rebecca
Karimi, Mobin
Targeting ITK signaling for T cell-mediated diseases
title Targeting ITK signaling for T cell-mediated diseases
title_full Targeting ITK signaling for T cell-mediated diseases
title_fullStr Targeting ITK signaling for T cell-mediated diseases
title_full_unstemmed Targeting ITK signaling for T cell-mediated diseases
title_short Targeting ITK signaling for T cell-mediated diseases
title_sort targeting itk signaling for t cell-mediated diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326193/
https://www.ncbi.nlm.nih.gov/pubmed/34368657
http://dx.doi.org/10.1016/j.isci.2021.102842
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