PGE2/EP4 skeleton interoception activity reduces vertebral endplate porosity and spinal pain with low-dose celecoxib

Skeletal interoception regulates bone homeostasis through the prostaglandin E2 (PGE2) concentration in bone. Vertebral endplates undergo ossification and become highly porous during intervertebral disc degeneration and aging. We found that the PGE2 concentration was elevated in porous endplates to g...

Descripción completa

Detalles Bibliográficos
Autores principales: Xue, Peng, Wang, Shenyu, Lyu, Xiao, Wan, Mei, Li, Xialin, Ma, Lei, Ford, Neil C., Li, Yukun, Guan, Yun, Ding, Wenyuan, Cao, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326284/
https://www.ncbi.nlm.nih.gov/pubmed/34334792
http://dx.doi.org/10.1038/s41413-021-00155-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326284/
https://www.ncbi.nlm.nih.gov/pubmed/34334792
http://dx.doi.org/10.1038/s41413-021-00155-z

Ejemplares similares