Transcriptional regulation of CYP19 by cohesin-mediated chromosome tethering in human granulosa cells

Human CYP19 spans a region of chromosome 15 of approximately 130 kb and encodes aromatase, an enzyme required for estrogen synthesis. In the human granulosa cell-line KGN, there are seven open chromatin regions within the CYP19 locus. In this study, we demonstrate that two of these regions ~40 kb up...

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Detalles Bibliográficos
Autores principales: Kotomura, Naoe, Harada, Nobuhiro, Shimono, Yohei, Ishihara, Satoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326343/
https://www.ncbi.nlm.nih.gov/pubmed/34368471
http://dx.doi.org/10.1016/j.bbrep.2021.101086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326343/
https://www.ncbi.nlm.nih.gov/pubmed/34368471
http://dx.doi.org/10.1016/j.bbrep.2021.101086

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