The RNA helicase DHX36–G4R1 modulates C9orf72 GGGGCC hexanucleotide repeat–associated translation

GGGGCC (G(4)C(2)) hexanucleotide repeat expansions in the endosomal trafficking gene C9orf72 are the most common genetic cause of ALS and frontotemporal dementia. Repeat-associated non-AUG (RAN) translation of this expansion through near-cognate initiation codon usage and internal ribosomal entry ge...

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Detalles Bibliográficos
Autores principales: Tseng, Yi-Ju, Sandwith, Siara N., Green, Katelyn M., Chambers, Antonio E., Krans, Amy, Raimer, Heather M., Sharlow, Meredith E., Reisinger, Michael A., Richardson, Adam E., Routh, Eric D., Smaldino, Melissa A., Wang, Yuh-Hwa, Vaughn, James P., Todd, Peter K., Smaldino, Philip J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326427/
https://www.ncbi.nlm.nih.gov/pubmed/34174288
http://dx.doi.org/10.1016/j.jbc.2021.100914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326427/
https://www.ncbi.nlm.nih.gov/pubmed/34174288
http://dx.doi.org/10.1016/j.jbc.2021.100914

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