Cargando…

Icariin Ameliorates Diabetic Renal Tubulointerstitial Fibrosis by Restoring Autophagy via Regulation of the miR-192-5p/GLP-1R Pathway

Tubulointerstitial fibrosis is one of the most common pathological features of diabetic nephropathy. Autophagy, an intracellular mechanism to remove damaged or dysfunctional cell parts and maintain metabolic homeostasis, is inhibited in diabetic neuropathy. Icariin is a traditional Chinese medicine...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jia, Zhirong, Wang, Kaiwei, Zhang, Yameng, Duan, Yalei, Xiao, Kang, Liu, Shuo, Ding, Xuansheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326523/ https://www.ncbi.nlm.nih.gov/pubmed/34349660 http://dx.doi.org/10.3389/fphar.2021.720387

Ejemplares similares

Claudin1 decrease induced by 1,25-dihydroxy-vitamin D3 potentiates gefitinib resistance therapy through inhibiting AKT activation-mediated cancer stem-like properties in NSCLC cells
por: Jia, Zhirong, et al.
Publicado: (2022)

miR-200b Precursor Can Ameliorate Renal Tubulointerstitial Fibrosis
por: Oba, Shigeyoshi, et al.
Publicado: (2010)

Low-dose paclitaxel ameliorates fibrosis in the remnant kidney model by down-regulating miR-192
por: Sun, Lin, et al.
Publicado: (2011)

Asiatic acid ameliorates tubulointerstitial fibrosis in mice with ureteral obstruction
por: XU, CHANGGENG, et al.
Publicado: (2013)

Gentiopicroside Ameliorates Diabetic Renal Tubulointerstitial Fibrosis via Inhibiting the AT1R/CK2/NF-κB Pathway
por: Xu, Zhanchi, et al.
Publicado: (2022)

miR-382 Contributes to Renal Tubulointerstitial Fibrosis by Downregulating HSPD1
por: Fang, Yi, et al.
Publicado: (2017)

Plk1 promotes renal tubulointerstitial fibrosis by targeting autophagy/lysosome axis
por: Du, Yang, et al.
Publicado: (2023)

Exendin-4 ameliorates high glucose-induced fibrosis by inhibiting the secretion of miR-192 from injured renal tubular epithelial cells
por: Jia, Yijie, et al.
Publicado: (2018)

PPARγ Agonist and Angiotensin II Receptor Antagonist Ameliorate Renal Tubulointerstitial Fibrosis
por: Han, Jee-Young, et al.
Publicado: (2010)

GLP-1 receptor agonist ameliorates experimental lung fibrosis
por: Fandiño, Juan, et al.
Publicado: (2020)

Is the proximal tubule the focus of tubulointerstitial fibrosis?
por: Peng, Zhi, et al.
Publicado: (2023)

Inhibition of lysyl oxidase‑like 2 ameliorates folic acid‑induced renal tubulointerstitial fibrosis
por: Choi, Sung-Eun, et al.
Publicado: (2022)

MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice
por: Kim, Yeawon, et al.
Publicado: (2023)

Icariin Attenuates OGD/R-Induced Autophagy via Bcl-2-Dependent Cross Talk between Apoptosis and Autophagy in PC12 Cells
por: Mo, Zhen-tao, et al.
Publicado: (2016)

Evaluation of the reactogenicity, adjuvanticity and antigenicity of LT(R192G) and LT(R192G/L211A) by intradermal immunization in mice
por: Maciel, Milton, et al.
Publicado: (2019)

Metformin attenuates renal tubulointerstitial fibrosis via upgrading autophagy in the early stage of diabetic nephropathy
por: Wang, Fengzhen, et al.
Publicado: (2021)

Icariin Prevents Extracellular Matrix Accumulation and Ameliorates Experimental Diabetic Kidney Disease by Inhibiting Oxidative Stress via GPER Mediated p62-Dependent Keap1 Degradation and Nrf2 Activation
por: Wang, Kai, et al.
Publicado: (2020)

Irisin Ameliorates Renal Tubulointerstitial Fibrosis by Regulating the Smad4/β-Catenin Pathway in Diabetic Mice
por: Yang, Zhaohua, et al.
Publicado: (2023)

1,25-dihydroxyvitamin D3 signaling-induced decreases in IRX4 inhibits NANOG-mediated cancer stem-like properties and gefitinib resistance in NSCLC cells
por: Jia, Zhirong, et al.
Publicado: (2020)

JuBei Oral Liquid Induces Mitochondria-Mediated Apoptosis in NSCLC Cells
por: Pan, Zhenzhen, et al.
Publicado: (2020)

Remdesivir Inhibits Tubulointerstitial Fibrosis in Obstructed Kidneys
por: Xu, Lin, et al.
Publicado: (2021)

MiR-192-5p Alleviated Fibrosis and Inflammatory Responses of Tendon Cells by Targeting NFAT5
por: Gong, Fan, et al.
Publicado: (2022)

Icariin Ameliorates Streptozotocin-Induced Diabetic Retinopathy in Vitro and in Vivo
por: Xin, Hua, et al.
Publicado: (2012)

Therapeutic Nanodiamonds Containing Icariin Ameliorate the Progression of Osteoarthritis in Rats
por: Yu, Ying, et al.
Publicado: (2023)

MicroRNA-22 Promotes Renal Tubulointerstitial Fibrosis by Targeting PTEN and Suppressing Autophagy in Diabetic Nephropathy
por: Zhang, Yingying, et al.
Publicado: (2018)

CTGF siRNA ameliorates tubular cell apoptosis and tubulointerstitial fibrosis in obstructed mouse kidneys in a Sirt1-independent manner
por: Ren, Yunzhuo, et al.
Publicado: (2015)

circHIPK3 Exacerbates Folic Acid-Induced Renal Tubulointerstitial Fibrosis by Sponging miR-30a
por: Wu, Yan, et al.
Publicado: (2022)

Inhibition of miR-25 Ameliorates Cardiac Dysfunction and Fibrosis by Restoring Krüppel-like Factor 4 Expression
por: Lee, Cholong, et al.
Publicado: (2023)

Trichostatin A ameliorates renal tubulointerstitial fibrosis through modulation of the JNK-dependent Notch-2 signaling pathway
por: Tung, Chun-Wu, et al.
Publicado: (2017)

Semicarbazide-sensitive amine oxidase inhibition ameliorates albuminuria and glomerulosclerosis but does not improve tubulointerstitial fibrosis in diabetic nephropathy
por: Wong, May YW, et al.
Publicado: (2020)

Inhibition of Yes-Associated Protein by Verteporfin Ameliorates Unilateral Ureteral Obstruction-Induced Renal Tubulointerstitial Inflammation and Fibrosis
por: Jin, Jixiu, et al.
Publicado: (2020)

A Novel Dipeptidyl Peptidase-4 Inhibitor DA-1229 Ameliorates Tubulointerstitial Fibrosis in Cyclosporine Nephrotoxicity in Mice
por: Min, Hye Sook, et al.
Publicado: (2021)

Cilomilast Ameliorates Renal Tubulointerstitial Fibrosis by Inhibiting the TGF-β1-Smad2/3 Signaling Pathway
por: Xu, Man, et al.
Publicado: (2021)

Dysregulation of exosomal miR-192 and miR-194 expression in lung adenocarcinoma patients
por: Wang, Tongfei, et al.
Publicado: (2021)

Dimethyl fumarate ameliorates cisplatin-induced renal tubulointerstitial lesions
por: Sasaki, Ayaka, et al.
Publicado: (2019)

TGF-β/Smad Signaling Pathway in Tubulointerstitial Fibrosis
por: Yu, Xiao-Yong, et al.
Publicado: (2022)

Emerging Role of MiR-192-5p in Human Diseases
por: Ren, Fu-jia, et al.
Publicado: (2021)

Serum levels of miR-29, miR-122, miR-155 and miR-192 are elevated in patients with cholangiocarcinoma
por: Loosen, Sven H., et al.
Publicado: (2019)

GLP-1 Treatment Improves Diabetic Retinopathy by Alleviating Autophagy through GLP-1R-ERK1/2-HDAC6 Signaling Pathway
por: Cai, Xiangsheng, et al.
Publicado: (2017)

Eucalyptol ameliorates Snail1/β-catenin-dependent diabetic disjunction of renal tubular epithelial cells and tubulointerstitial fibrosis
por: Kim, Dong Yeon, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_rthg1a428gljtkcrs8rmdpr71l