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CPI-637 as a Potential Bifunctional Latency-Reversing Agent That Targets Both the BRD4 and TIP60 Proteins

The failure of highly active antiretroviral therapy (HAART) has been largely responsible for the existence of latent human immunodeficiency virus type 1 (HIV-1) reservoirs. The “shock and kill” strategy was confirmed to reactivate HIV-1 latent reservoirs by latency-reversing agents (LRAs) for accele...

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Detalles Bibliográficos
Autores principales: Zheng, Tengyi, Chen, Pei, Huang, Yifan, Qiu, Jiayin, Zhou, Chenliang, Wu, Ziyao, Li, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326664/
https://www.ncbi.nlm.nih.gov/pubmed/34350133
http://dx.doi.org/10.3389/fcimb.2021.686035