Branebrutinib (BMS-986195), a Bruton’s Tyrosine Kinase Inhibitor, Resensitizes P-Glycoprotein-Overexpressing Multidrug-Resistant Cancer Cells to Chemotherapeutic Agents

The overexpression of P-glycoprotein (P-gp/ABCB1), an ATP-binding cassette (ABC) drug transporter, often contributes to the development of multidrug resistance (MDR) in cancer cells. P-gp mediates the ATP hydrolysis-dependent efflux of a wide range of chemotherapeutic agents out of cancer cells, the...

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Detalles Bibliográficos
Autores principales: Wu, Chung-Pu, Murakami, Megumi, Wu, Yu-Shan, Chi, Ya-Chen, Hsiao, Sung-Han, Huang, Yang-Hui, Hung, Tai-Ho, Ambudkar, Suresh V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326665/
https://www.ncbi.nlm.nih.gov/pubmed/34350184
http://dx.doi.org/10.3389/fcell.2021.699571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326665/
https://www.ncbi.nlm.nih.gov/pubmed/34350184
http://dx.doi.org/10.3389/fcell.2021.699571

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