An allosteric redox switch in domain V of β(2)-glycoprotein I controls membrane binding and anti-domain I autoantibody recognition

β(2)-glycoprotein I (β(2)GPI) is an abundant multidomain plasma protein that plays various roles in the clotting and complement cascades. It is also the main target of antiphospholipid antibodies (aPL) in the acquired coagulopathy known as antiphospholipid syndrome (APS). Previous studies have shown...

Descripción completa

Detalles Bibliográficos
Autores principales: Kumar, Suresh, Chinnaraj, Mathivanan, Planer, William, Zuo, Xiaobing, Macor, Paolo, Tedesco, Francesco, Pozzi, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326733/
https://www.ncbi.nlm.nih.gov/pubmed/34197876
http://dx.doi.org/10.1016/j.jbc.2021.100890

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326733/
https://www.ncbi.nlm.nih.gov/pubmed/34197876
http://dx.doi.org/10.1016/j.jbc.2021.100890

Ejemplares similares