Relationship Between Amyloid-β Deposition and Blood–Brain Barrier Dysfunction in Alzheimer’s Disease

Amyloid-β (Aβ) is the predominant pathologic protein in Alzheimer’s disease (AD). The production and deposition of Aβ are important factors affecting AD progression and prognosis. The deposition of neurotoxic Aβ contributes to damage of the blood–brain barrier. However, the BBB is also crucial in ma...

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Autores principales: Wang, Dong, Chen, Fanglian, Han, Zhaoli, Yin, Zhenyu, Ge, Xintong, Lei, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326917/
https://www.ncbi.nlm.nih.gov/pubmed/34349624
http://dx.doi.org/10.3389/fncel.2021.695479
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author Wang, Dong
Chen, Fanglian
Han, Zhaoli
Yin, Zhenyu
Ge, Xintong
Lei, Ping
author_facet Wang, Dong
Chen, Fanglian
Han, Zhaoli
Yin, Zhenyu
Ge, Xintong
Lei, Ping
author_sort Wang, Dong
collection PubMed
description Amyloid-β (Aβ) is the predominant pathologic protein in Alzheimer’s disease (AD). The production and deposition of Aβ are important factors affecting AD progression and prognosis. The deposition of neurotoxic Aβ contributes to damage of the blood–brain barrier. However, the BBB is also crucial in maintaining the normal metabolism of Aβ, and dysfunction of the BBB aggravates Aβ deposition. This review characterizes Aβ deposition and BBB damage in AD, summarizes their interactions, and details their respective mechanisms.
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spelling pubmed-83269172021-08-03 Relationship Between Amyloid-β Deposition and Blood–Brain Barrier Dysfunction in Alzheimer’s Disease Wang, Dong Chen, Fanglian Han, Zhaoli Yin, Zhenyu Ge, Xintong Lei, Ping Front Cell Neurosci Neuroscience Amyloid-β (Aβ) is the predominant pathologic protein in Alzheimer’s disease (AD). The production and deposition of Aβ are important factors affecting AD progression and prognosis. The deposition of neurotoxic Aβ contributes to damage of the blood–brain barrier. However, the BBB is also crucial in maintaining the normal metabolism of Aβ, and dysfunction of the BBB aggravates Aβ deposition. This review characterizes Aβ deposition and BBB damage in AD, summarizes their interactions, and details their respective mechanisms. Frontiers Media S.A. 2021-07-19 /pmc/articles/PMC8326917/ /pubmed/34349624 http://dx.doi.org/10.3389/fncel.2021.695479 Text en Copyright © 2021 Wang, Chen, Han, Yin, Ge and Lei. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Wang, Dong
Chen, Fanglian
Han, Zhaoli
Yin, Zhenyu
Ge, Xintong
Lei, Ping
Relationship Between Amyloid-β Deposition and Blood–Brain Barrier Dysfunction in Alzheimer’s Disease
title Relationship Between Amyloid-β Deposition and Blood–Brain Barrier Dysfunction in Alzheimer’s Disease
title_full Relationship Between Amyloid-β Deposition and Blood–Brain Barrier Dysfunction in Alzheimer’s Disease
title_fullStr Relationship Between Amyloid-β Deposition and Blood–Brain Barrier Dysfunction in Alzheimer’s Disease
title_full_unstemmed Relationship Between Amyloid-β Deposition and Blood–Brain Barrier Dysfunction in Alzheimer’s Disease
title_short Relationship Between Amyloid-β Deposition and Blood–Brain Barrier Dysfunction in Alzheimer’s Disease
title_sort relationship between amyloid-β deposition and blood–brain barrier dysfunction in alzheimer’s disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8326917/
https://www.ncbi.nlm.nih.gov/pubmed/34349624
http://dx.doi.org/10.3389/fncel.2021.695479
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