Cargando…

PEGylated AdipoRon derivatives improve glucose and lipid metabolism under insulinopenic and high-fat diet conditions

The pleiotropic actions of adiponectin in improving cell survival and metabolism have motivated the development of small-molecule therapeutic agents for treating diabetes and lipotoxicity. AdipoRon is a synthetic agonist of the adiponectin receptors, yet is limited by its poor solubility and bioavai...

Descripción completa

Detalles Bibliográficos
Autores principales:	Onodera, Toshiharu, Ghazvini Zadeh, Ebrahim, Xu, Peng, Gordillo, Ruth, Guo, Zheng, Joffin, Nolwenn, Yu, Biao, Scherer, Philipp E., Li, Wen-hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327158/ https://www.ncbi.nlm.nih.gov/pubmed/34214600 http://dx.doi.org/10.1016/j.jlr.2021.100095

Ejemplares similares

AdipoRon may be benefit for atherosclerosis prevention
por: Esfahani, Maryam, et al.
Publicado: (2017)

AdipoRon, a new therapeutic prospect for Duchenne muscular dystrophy
por: Abou‐Samra, Michel, et al.
Publicado: (2020)

Protective effects of AdipoRon on the liver of Huoyan goose fed a high-fat diet
por: Cao, Zhongzan, et al.
Publicado: (2022)

AdipoRon Engages Microglia to Antinociception through the AdipoR1/AMPK Pathway in SNI Mice
por: Fang, Qian, et al.
Publicado: (2023)

AdipoRon and Other Adiponectin Receptor Agonists as Potential Candidates in Cancer Treatments
por: Nigro, Ersilia, et al.
Publicado: (2021)

Adiponectin receptor agonist AdipoRon relieves endotoxin-induced acute hepatitis in mice
por: Xiao, Wen-Ze, et al.
Publicado: (2019)

AdipoRon Affects Cell Cycle Progression and Inhibits Proliferation in Human Osteosarcoma Cells
por: Sapio, Luigi, et al.
Publicado: (2020)

AdipoRon Treatment Induces a Dose-Dependent Response in Adult Hippocampal Neurogenesis
por: Lee, Thomas H., et al.
Publicado: (2021)

Adiponectin receptor agonist AdipoRon improves skeletal muscle function in aged mice
por: Balasubramanian, Priya, et al.
Publicado: (2022)

AdipoRon Promotes the Osseointegration of Dental Implants in Mice With Type 2 Diabetes Mellitus
por: Huang, BoRui, et al.
Publicado: (2021)

AdipoRon accelerates bone repair of calvarial defect in diet-induced obesity mice
por: Wu, Xingwen, et al.
Publicado: (2023)

AdipoRon Protects against Tubular Injury in Diabetic Nephropathy by Inhibiting Endoplasmic Reticulum Stress
por: Xiong, Shan, et al.
Publicado: (2020)

Synthetic adiponectin-receptor agonist, AdipoRon, induces glycolytic dependence in pancreatic cancer cells
por: Manley, Sharon J., et al.
Publicado: (2022)

Adiponectin receptor agonist AdipoRon blocks skin inflamm‐ageing by regulating mitochondrial dynamics
por: Sun, Jiachen, et al.
Publicado: (2021)

AdipoRon and Pancreatic Ductal Adenocarcinoma: a future perspective in overcoming chemotherapy-induced resistance?
por: Sapio, Luigi, et al.
Publicado: (2022)

Anti-Inflammatory Effects of Adiponectin Receptor Agonist AdipoRon against Intervertebral Disc Degeneration
por: Ohnishi, Hiroki, et al.
Publicado: (2023)

Chronic AdipoRon Treatment Mimics the Effects of Physical Exercise on Restoring Hippocampal Neuroplasticity in Diabetic Mice
por: Lee, Thomas H, et al.
Publicado: (2021)

Correction: Synthetic adiponectin-receptor agonist, AdipoRon, induces glycolytic dependence in pancreatic cancer cells
por: Manley, Sharon J., et al.
Publicado: (2022)

Integrating Gemcitabine-Based Therapy With AdipoRon Enhances Growth Inhibition in Human PDAC Cell Lines
por: Ragone, Angela, et al.
Publicado: (2022)

AdipoRon, an Orally Active, Synthetic Agonist of AdipoR1 and AdipoR2 Receptors Has Gastroprotective Effect in Experimentally Induced Gastric Ulcers in Mice
por: Zatorski, Hubert, et al.
Publicado: (2021)

AdipoRon, adiponectin receptor agonist, improves vascular function in the mesenteric arteries of type 2 diabetic mice
por: Choi, Soo-Kyoung, et al.
Publicado: (2020)

Obesity reduces the anticancer effect of AdipoRon against orthotopic pancreatic cancer in diet-induced obese mice
por: Takenaga, Keizo, et al.
Publicado: (2021)

AdipoRon enhances healthspan in middle‐aged obese mice: striking alleviation of myosteatosis and muscle degenerative markers
por: Selvais, Camille M., et al.
Publicado: (2022)

AdipoRon Attenuates Inflammation and Impairment of Cardiac Function Associated With Cardiopulmonary Bypass–Induced Systemic Inflammatory Response Syndrome
por: Jenke, Alexander, et al.
Publicado: (2021)

AdipoRon prevents myostatin‐induced upregulation of fatty acid synthesis and downregulation of insulin activity in a mouse hepatocyte line
por: Liu, Xin‐Hua, et al.
Publicado: (2019)

AdipoRon Alleviates Free Fatty Acid-Induced Myocardial Cell Injury Via Suppressing Nlrp3 Inflammasome Activation
por: Zhang, You-Zhi, et al.
Publicado: (2019)

AdipoRon exerts opposing effects on insulin sensitivity via fibroblast growth factor 21–mediated time-dependent mechanisms
por: Wang, Yongliang, et al.
Publicado: (2022)

AdipoRon Inhibits Neuroinflammation Induced by Deep Hypothermic Circulatory Arrest Involving the AMPK/NF-κB Pathway in Rats
por: Yan, Weidong, et al.
Publicado: (2022)

A stem cell based in vitro model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference
por: Graffmann, Nina, et al.
Publicado: (2021)

Antidiabetic adiponectin receptor agonist AdipoRon suppresses tumour growth of pancreatic cancer by inducing RIPK1/ERK-dependent necroptosis
por: Akimoto, Miho, et al.
Publicado: (2018)

Distribution of Adiponectin Receptors in the Brain of Adult Mouse: Effect of a Single Dose of the Adiponectin Receptor Agonist, AdipoRON, on Ischemic Stroke
por: Clain, Julien, et al.
Publicado: (2022)

The adiponectin receptor agonist, AdipoRon, promotes reproductive hormone secretion and gonadal development via the hypothalamic-pituitary-gonadal axis in chickens
por: Li, Chong, et al.
Publicado: (2022)

Increasing Adiponectin Signaling by Sub-Chronic AdipoRon Treatment Elicits Antidepressant- and Anxiolytic-Like Effects Independent of Changes in Hippocampal Plasticity
por: Formolo, Douglas A., et al.
Publicado: (2023)

Adiponectin receptor agonist AdipoRon ameliorates renal inflammation in diet-induced obese mice and endotoxin-treated human glomeruli ex vivo
por: Lindfors, Sonja, et al.
Publicado: (2021)

β-Cell Succinate Dehydrogenase Deficiency Triggers Metabolic Dysfunction and Insulinopenic Diabetes
por: Lee, Sooyeon, et al.
Publicado: (2022)

Fabp4, a new player in the adipo-pancreatic axis
por: Ye, Risheng, et al.
Publicado: (2014)

Pegylated and nanoparticle-conjugated sulfonium salt photo triggers necrotic cell death
por: Fadhel, Alaa A, et al.
Publicado: (2016)

A Low-Carbohydrate Diet Improves Glucose Metabolism in Lean Insulinopenic Akita Mice Along With Sodium-Glucose Cotransporter 2 Inhibitor
por: Fujita, Yukihiro, et al.
Publicado: (2020)

Acute induction of uncoupling protein 1 by citrulline in cultured explants of white adipose tissue from lean and high-fat-diet-fed rats
por: Joffin, Nolwenn, et al.
Publicado: (2015)

Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis
por: An, Yu A, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_luesejvc43tvndbpcdnuie1esg