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Heart Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 Gene Expression Associated With Male Sex and Salt-Sensitive Hypertension in the Dahl Rat

Angiotensin-converting enzyme 2 (ACE 2) in the heart including its sex dependency in the hypertensive heart, has not been much studied compared to ACE. In the present study, we used the Dahl salt-sensitive rat exposed to fructose and salt to model a hypertensive phenotype in males, females, and ovar...

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Autores principales: Ytrehus, Kirsti, Ludvigsen, Stian, Mancusi, Costantino, Gerdts, Eva, de Simone, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327162/
https://www.ncbi.nlm.nih.gov/pubmed/34349662
http://dx.doi.org/10.3389/fphys.2021.663819
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author Ytrehus, Kirsti
Ludvigsen, Stian
Mancusi, Costantino
Gerdts, Eva
de Simone, Giovanni
author_facet Ytrehus, Kirsti
Ludvigsen, Stian
Mancusi, Costantino
Gerdts, Eva
de Simone, Giovanni
author_sort Ytrehus, Kirsti
collection PubMed
description Angiotensin-converting enzyme 2 (ACE 2) in the heart including its sex dependency in the hypertensive heart, has not been much studied compared to ACE. In the present study, we used the Dahl salt-sensitive rat exposed to fructose and salt to model a hypertensive phenotype in males, females, and ovariectomized females. Blood pressure was measured by the tale-cuff technique in the conscious state. Expression of RAS-related genes ACE, ACE2, angiotensin II receptor type 1, Mas1, and CMA1 in the heart were quantified. The results revealed small but significant differences between male and female groups. The main results indicate the presence of a male preponderance for an increase in ACE and ACE2 gene expression. The results are in accordance with the role of androgens or male chromosomal complement in controlling the expression of the two ACE genes.
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spelling pubmed-83271622021-08-03 Heart Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 Gene Expression Associated With Male Sex and Salt-Sensitive Hypertension in the Dahl Rat Ytrehus, Kirsti Ludvigsen, Stian Mancusi, Costantino Gerdts, Eva de Simone, Giovanni Front Physiol Physiology Angiotensin-converting enzyme 2 (ACE 2) in the heart including its sex dependency in the hypertensive heart, has not been much studied compared to ACE. In the present study, we used the Dahl salt-sensitive rat exposed to fructose and salt to model a hypertensive phenotype in males, females, and ovariectomized females. Blood pressure was measured by the tale-cuff technique in the conscious state. Expression of RAS-related genes ACE, ACE2, angiotensin II receptor type 1, Mas1, and CMA1 in the heart were quantified. The results revealed small but significant differences between male and female groups. The main results indicate the presence of a male preponderance for an increase in ACE and ACE2 gene expression. The results are in accordance with the role of androgens or male chromosomal complement in controlling the expression of the two ACE genes. Frontiers Media S.A. 2021-07-19 /pmc/articles/PMC8327162/ /pubmed/34349662 http://dx.doi.org/10.3389/fphys.2021.663819 Text en Copyright © 2021 Ytrehus, Ludvigsen, Mancusi, Gerdts and de Simone. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Ytrehus, Kirsti
Ludvigsen, Stian
Mancusi, Costantino
Gerdts, Eva
de Simone, Giovanni
Heart Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 Gene Expression Associated With Male Sex and Salt-Sensitive Hypertension in the Dahl Rat
title Heart Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 Gene Expression Associated With Male Sex and Salt-Sensitive Hypertension in the Dahl Rat
title_full Heart Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 Gene Expression Associated With Male Sex and Salt-Sensitive Hypertension in the Dahl Rat
title_fullStr Heart Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 Gene Expression Associated With Male Sex and Salt-Sensitive Hypertension in the Dahl Rat
title_full_unstemmed Heart Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 Gene Expression Associated With Male Sex and Salt-Sensitive Hypertension in the Dahl Rat
title_short Heart Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 Gene Expression Associated With Male Sex and Salt-Sensitive Hypertension in the Dahl Rat
title_sort heart angiotensin-converting enzyme and angiotensin-converting enzyme 2 gene expression associated with male sex and salt-sensitive hypertension in the dahl rat
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327162/
https://www.ncbi.nlm.nih.gov/pubmed/34349662
http://dx.doi.org/10.3389/fphys.2021.663819
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