Cargando…

Regulation of a pentameric ligand-gated ion channel by a semiconserved cationic lipid-binding site

Pentameric ligand-gated ion channels (pLGICs) are crucial mediators of electrochemical signal transduction in various organisms from bacteria to humans. Lipids play an important role in regulating pLGIC function, yet the structural bases for specific pLGIC-lipid interactions remain poorly understood...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sridhar, Akshay, Lummis, Sarah C.R., Pasini, Diletta, Mehregan, Aujan, Brams, Marijke, Kambara, Kumiko, Bertrand, Daniel, Lindahl, Erik, Howard, Rebecca J., Ulens, Chris
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327344/ https://www.ncbi.nlm.nih.gov/pubmed/34157288 http://dx.doi.org/10.1016/j.jbc.2021.100899

Ejemplares similares

Multisite Binding of a General Anesthetic to the Prokaryotic Pentameric Erwinia chrysanthemi Ligand-gated Ion Channel (ELIC)
por: Spurny, Radovan, et al.
Publicado: (2013)

Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT(3) receptor via a common vestibule site
por: Brams, Marijke, et al.
Publicado: (2020)

The molecular mechanism of snake short-chain α-neurotoxin binding to muscle-type nicotinic acetylcholine receptors
por: Nys, Mieke, et al.
Publicado: (2022)

Probing effects of the SARS-CoV-2 E protein on membrane curvature and intracellular calcium
por: Mehregan, Aujan, et al.
Publicado: (2022)

Inhibition of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC by Divalent Cations
por: Zimmermann, Iwan, et al.
Publicado: (2012)

Structural Basis for Xenon Inhibition in a Cationic Pentameric Ligand-Gated Ion Channel
por: Sauguet, Ludovic, et al.
Publicado: (2016)

The atypical cation-conduction and gating properties of ELIC underscore the marked functional versatility of the pentameric ligand-gated ion-channel fold
por: Gonzalez-Gutierrez, Giovanni, et al.
Publicado: (2015)

Ligand Activation of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC
por: Zimmermann, Iwan, et al.
Publicado: (2011)

Markov state models of proton- and pore-dependent activation in a pentameric ligand-gated ion channel
por: Bergh, Cathrine, et al.
Publicado: (2021)

Signal Transduction Pathways in the Pentameric Ligand-Gated Ion Channels
por: Mowrey, David, et al.
Publicado: (2013)

Biophysical characterization of calcium-binding and modulatory-domain dynamics in a pentameric ligand-gated ion channel
por: Lycksell, Marie, et al.
Publicado: (2022)

The pharmacological profile of ELIC, a prokaryotic GABA-gated receptor
por: Thompson, Andrew J., et al.
Publicado: (2012)

Probing solution structure of the pentameric ligand-gated ion channel GLIC by small-angle neutron scattering
por: Lycksell, Marie, et al.
Publicado: (2021)

Evolution of Pentameric Ligand-Gated Ion Channels: Pro-Loop Receptors
por: Jaiteh, Mariama, et al.
Publicado: (2016)

Chasing the open-state structure of pentameric ligand-gated ion channels
por: Gonzalez-Gutierrez, Giovanni, et al.
Publicado: (2017)

Molecular Mingling: Multimodal Predictions of Ligand Promiscuity in Pentameric Ligand-Gated Ion Channels
por: Koniuszewski, Filip, et al.
Publicado: (2022)

Site-Directed Spin Labeling Reveals Pentameric Ligand-Gated Ion Channel Gating Motions
por: Dellisanti, Cosma D., et al.
Publicado: (2013)

Molecular Simulations of Hydrophobic Gating of Pentameric Ligand Gated Ion Channels: Insights into Water and Ions
por: Rao, Shanlin, et al.
Publicado: (2021)

Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels
por: Sauguet, Ludovic, et al.
Publicado: (2013)

Allosteric regulation of pentameric ligand-gated ion channels: An emerging mechanistic perspective
por: Taly, Antoine, et al.
Publicado: (2014)

Signal Transduction at the Domain Interface of Prokaryotic Pentameric Ligand-Gated Ion Channels
por: Bertozzi, Carlo, et al.
Publicado: (2016)

Pentameric Ligand-Gated Ion Channels as Pharmacological Targets Against Chronic Pain
por: Lara, César O., et al.
Publicado: (2020)

A Single Mutation in the Outer Lipid-Facing Helix of a Pentameric Ligand-Gated Ion Channel Affects Channel Function Through a Radially-Propagating Mechanism
por: Crnjar, Alessandro, et al.
Publicado: (2021)

Un-gating and allosteric modulation of a pentameric ligand-gated ion channel captured by molecular dynamics
por: Martin, Nicolas E, et al.
Publicado: (2017)

Antibodies to Peptides in Semiconserved Domains of RIFINs and STEVORs Correlate with Malaria Exposure
por: Zhou, Albert E., et al.
Publicado: (2019)

Different Ligands of the TRPV3 Cation Channel Cause Distinct Conformational Changes as Revealed by Intrinsic Tryptophan Fluorescence Quenching
por: Billen, Bert, et al.
Publicado: (2015)

Correction: Signal Transduction at the Domain Interface of Prokaryotic Pentameric Ligand-Gated Ion Channels
Publicado: (2016)

A chimeric prokaryotic pentameric ligand–gated channel reveals distinct pathways of activation
por: Schmandt, Nicolaus, et al.
Publicado: (2015)

Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels
por: Lynagh, Timothy, et al.
Publicado: (2015)

Recent Insight into Lipid Binding and Lipid Modulation of Pentameric Ligand-Gated Ion Channels
por: Ananchenko, Anna, et al.
Publicado: (2022)

Origin of acetylcholine antagonism in ELIC, a bacterial pentameric ligand-gated ion channel
por: Slobodyanyuk, Mykhaylo, et al.
Publicado: (2022)

Varenicline Interactions at the 5-HT(3) Receptor Ligand Binding Site are Revealed by 5-HTBP
por: Price, Kerry L., et al.
Publicado: (2015)

Structural basis of ligand recognition in 5-HT(3) receptors
por: Kesters, Divya, et al.
Publicado: (2013)

Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine
por: Pan, Jianjun, et al.
Publicado: (2012)

Trapping of ivermectin by a pentameric ligand-gated ion channel upon open-to-closed isomerization
por: Degani-Katzav, Nurit, et al.
Publicado: (2017)

Structure of the SthK Carboxy-Terminal Region Reveals a Gating Mechanism for Cyclic Nucleotide-Modulated Ion Channels
por: Kesters, Divya, et al.
Publicado: (2015)

Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC
por: Chen, Qiang, et al.
Publicado: (2015)

Pentameric ligand-gated ion channels exhibit distinct transmembrane domain archetypes for folding/expression and function
por: Therien, J. P. Daniel, et al.
Publicado: (2017)

Druggable Lipid Binding Sites in Pentameric Ligand-Gated Ion Channels and Transient Receptor Potential Channels
por: Cheng, Wayland W. L., et al.
Publicado: (2022)

Decrypting the Sequence of Structural Events during the Gating Transition of Pentameric Ligand-Gated Ion Channels Based on an Interpolated Elastic Network Model
por: Zheng, Wenjun, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_3gbrfvpmvdimls020eveh4d82r