Mechanistic basis for chromosomal translocations at the E2A gene and its broader relevance to human B cell malignancies

Analysis of translocation breakpoints in human B cell malignancies reveals that DNA double-strand breaks at oncogenes most frequently occur at CpG sites located within 20–600 bp fragile zones and depend on activation-induced deaminase (AID). AID requires single-stranded DNA (ssDNA) to act, but it ha...

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Detalles Bibliográficos
Autores principales: Liu, Di, Eddie Loh, Yong-Hwee, Hsieh, Chih-Lin, Lieber, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327686/
https://www.ncbi.nlm.nih.gov/pubmed/34260910
http://dx.doi.org/10.1016/j.celrep.2021.109387

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327686/
https://www.ncbi.nlm.nih.gov/pubmed/34260910
http://dx.doi.org/10.1016/j.celrep.2021.109387

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