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Mechanistic basis for chromosomal translocations at the E2A gene and its broader relevance to human B cell malignancies
Analysis of translocation breakpoints in human B cell malignancies reveals that DNA double-strand breaks at oncogenes most frequently occur at CpG sites located within 20–600 bp fragile zones and depend on activation-induced deaminase (AID). AID requires single-stranded DNA (ssDNA) to act, but it ha...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327686/ https://www.ncbi.nlm.nih.gov/pubmed/34260910 http://dx.doi.org/10.1016/j.celrep.2021.109387 |