Statin-mediated inhibition of RAS prenylation activates ER stress to enhance the immunogenicity of KRAS mutant cancer

BACKGROUND: Statins preferentially promote tumor-specific apoptosis by depleting isoprenoid such as farnesyl pyrophosphate and geranylgeranyl pyrophosphate. However, statins have not yet been approved for clinical cancer treatment due, in part, to poor understanding of molecular determinants on stat...

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Detalles Bibliográficos
Autores principales: Nam, Gi-Hoon, Kwon, Minsu, Jung, Hanul, Ko, Eunbyeol, Kim, Seong A, Choi, Yoonjeong, Song, Su Jeong, Kim, Seohyun, Lee, Yeji, Kim, Gi Beom, Han, Jihoon, Woo, Jiwan, Cho, Yakdol, Jeong, Cherlhyun, Park, Seung-Yoon, Roberts, Thomas M., Cho, Yong Beom, Kim, In-San
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327837/
https://www.ncbi.nlm.nih.gov/pubmed/34330763
http://dx.doi.org/10.1136/jitc-2021-002474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327837/
https://www.ncbi.nlm.nih.gov/pubmed/34330763
http://dx.doi.org/10.1136/jitc-2021-002474

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