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Food sources of dietary fibre and risk of total knee replacement related to severe osteoarthritis, the Singapore Chinese Health Study

OBJECTIVES: We aimed to evaluate the association between fibre intake and its food sources, and the risk of total knee replacement (TKR) due to severe knee osteoarthritis (KOA). METHODS: We used data from the Singapore Chinese Health Study, a prospective cohort study that recruited 63 257 participan...

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Autores principales: Leung, Ying Ying, Jin, Aizhen, Tan, Kelvin Bryan, Ang, Li-Wei, Yuan, Jian-Min, Koh, Woon-Puay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327838/
https://www.ncbi.nlm.nih.gov/pubmed/34330847
http://dx.doi.org/10.1136/rmdopen-2021-001602
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author Leung, Ying Ying
Jin, Aizhen
Tan, Kelvin Bryan
Ang, Li-Wei
Yuan, Jian-Min
Koh, Woon-Puay
author_facet Leung, Ying Ying
Jin, Aizhen
Tan, Kelvin Bryan
Ang, Li-Wei
Yuan, Jian-Min
Koh, Woon-Puay
author_sort Leung, Ying Ying
collection PubMed
description OBJECTIVES: We aimed to evaluate the association between fibre intake and its food sources, and the risk of total knee replacement (TKR) due to severe knee osteoarthritis (KOA). METHODS: We used data from the Singapore Chinese Health Study, a prospective cohort study that recruited 63 257 participants aged 45–74 years from 1993 to 1998. At baseline, we assessed diet using a validated 165-item semiquantitative food frequency questionnaire, together with body mass index (BMI) and lifestyle factors. Incident TKR cases were identified via record linkage with nationwide hospital discharge database through 2017. RESULTS: There were 2816 cases of incident TKR due to severe KOA. The total fibre intake at baseline was not associated with the risk of TKR after adjustment for confounders. Among the food sources of fibre, higher intake of legumes was associated with a lower risk of TKR in a dose-dependent manner; compared with those having the lowest quartile intake, HR (95% CI) was 0.86 (0.76, 0.96) for those having the highest quartile intake (p for trend=0.004). This association was consistent after including BMI in the model and homogeneous across BMI categories. The consumption of other fibre sources, namely grain products, nuts and seeds, soy food, fruits and vegetables, was not associated with the risk of TKR. CONCLUSION: Intake of legumes, but not total fibre, was associated with a reduced risk of TKR. Further research is needed to replicate our findings and to evaluate possible biological mechanisms that could explain the effect of dietary legumes on pathogenesis or progression of KOA.
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spelling pubmed-83278382021-08-19 Food sources of dietary fibre and risk of total knee replacement related to severe osteoarthritis, the Singapore Chinese Health Study Leung, Ying Ying Jin, Aizhen Tan, Kelvin Bryan Ang, Li-Wei Yuan, Jian-Min Koh, Woon-Puay RMD Open Osteoarthritis OBJECTIVES: We aimed to evaluate the association between fibre intake and its food sources, and the risk of total knee replacement (TKR) due to severe knee osteoarthritis (KOA). METHODS: We used data from the Singapore Chinese Health Study, a prospective cohort study that recruited 63 257 participants aged 45–74 years from 1993 to 1998. At baseline, we assessed diet using a validated 165-item semiquantitative food frequency questionnaire, together with body mass index (BMI) and lifestyle factors. Incident TKR cases were identified via record linkage with nationwide hospital discharge database through 2017. RESULTS: There were 2816 cases of incident TKR due to severe KOA. The total fibre intake at baseline was not associated with the risk of TKR after adjustment for confounders. Among the food sources of fibre, higher intake of legumes was associated with a lower risk of TKR in a dose-dependent manner; compared with those having the lowest quartile intake, HR (95% CI) was 0.86 (0.76, 0.96) for those having the highest quartile intake (p for trend=0.004). This association was consistent after including BMI in the model and homogeneous across BMI categories. The consumption of other fibre sources, namely grain products, nuts and seeds, soy food, fruits and vegetables, was not associated with the risk of TKR. CONCLUSION: Intake of legumes, but not total fibre, was associated with a reduced risk of TKR. Further research is needed to replicate our findings and to evaluate possible biological mechanisms that could explain the effect of dietary legumes on pathogenesis or progression of KOA. BMJ Publishing Group 2021-07-30 /pmc/articles/PMC8327838/ /pubmed/34330847 http://dx.doi.org/10.1136/rmdopen-2021-001602 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Osteoarthritis
Leung, Ying Ying
Jin, Aizhen
Tan, Kelvin Bryan
Ang, Li-Wei
Yuan, Jian-Min
Koh, Woon-Puay
Food sources of dietary fibre and risk of total knee replacement related to severe osteoarthritis, the Singapore Chinese Health Study
title Food sources of dietary fibre and risk of total knee replacement related to severe osteoarthritis, the Singapore Chinese Health Study
title_full Food sources of dietary fibre and risk of total knee replacement related to severe osteoarthritis, the Singapore Chinese Health Study
title_fullStr Food sources of dietary fibre and risk of total knee replacement related to severe osteoarthritis, the Singapore Chinese Health Study
title_full_unstemmed Food sources of dietary fibre and risk of total knee replacement related to severe osteoarthritis, the Singapore Chinese Health Study
title_short Food sources of dietary fibre and risk of total knee replacement related to severe osteoarthritis, the Singapore Chinese Health Study
title_sort food sources of dietary fibre and risk of total knee replacement related to severe osteoarthritis, the singapore chinese health study
topic Osteoarthritis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327838/
https://www.ncbi.nlm.nih.gov/pubmed/34330847
http://dx.doi.org/10.1136/rmdopen-2021-001602
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