The Ceiling Effect, the Floor Effect, and the Importance of Active and Placebo Control Arms in Randomized Controlled Trials of an Investigational Drug

Randomized controlled trials (RCTs) of a new investigational drug often include active as well as placebo control arms. The active arm, comprising an approved treatment for the indication under study, along with the placebo arm, are together required to establish assay sensitivity; if the active tre...

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Detalles Bibliográficos
Autor principal: Andrade, Chittaranjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Learning Curve
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327873/
https://www.ncbi.nlm.nih.gov/pubmed/34385732
http://dx.doi.org/10.1177/02537176211021280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327873/
https://www.ncbi.nlm.nih.gov/pubmed/34385732
http://dx.doi.org/10.1177/02537176211021280

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