Pathogenic germline IKZF1 variant alters hematopoietic gene expression profiles

IKZF1 encodes Ikaros, a zinc finger–containing transcription factor crucial to the development of the hematopoietic system. Germline pathogenic variants in IKZF1 have been reported in patients with acute lymphocytic leukemia and immunodeficiency syndromes. Diamond–Blackfan anemia (DBA) is a rare inh...

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Detalles Bibliográficos
Autores principales: Brodie, Seth A., Khincha, Payal P., Giri, Neelam, Bouk, Aaron J., Steinberg, Mia, Dai, Jieqiong, Jessop, Lea, Donovan, Frank X., Chandrasekharappa, Settara C., de Andrade, Kelvin C., Maric, Irina, Ellis, Steven R., Mirabello, Lisa, Alter, Blanche P., Savage, Sharon A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327879/
https://www.ncbi.nlm.nih.gov/pubmed/34162668
http://dx.doi.org/10.1101/mcs.a006015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327879/
https://www.ncbi.nlm.nih.gov/pubmed/34162668
http://dx.doi.org/10.1101/mcs.a006015

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