Acute depletion of METTL3 implicates N(6)-methyladenosine in alternative intron/exon inclusion in the nascent transcriptome

RNA N(6)-methyladenosine (m(6)A) modification plays important roles in multiple aspects of RNA regulation. m(6)A is installed cotranscriptionally by the METTL3/14 complex, but its direct roles in RNA processing remain unclear. Here, we investigate the presence of m(6)A in nascent RNA of mouse embryo...

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Detalles Bibliográficos
Autores principales: Wei, Guifeng, Almeida, Mafalda, Pintacuda, Greta, Coker, Heather, Bowness, Joseph S., Ule, Jernej, Brockdorff, Neil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327914/
https://www.ncbi.nlm.nih.gov/pubmed/34131006
http://dx.doi.org/10.1101/gr.271635.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327914/
https://www.ncbi.nlm.nih.gov/pubmed/34131006
http://dx.doi.org/10.1101/gr.271635.120

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