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Acute depletion of METTL3 implicates N(6)-methyladenosine in alternative intron/exon inclusion in the nascent transcriptome

RNA N(6)-methyladenosine (m(6)A) modification plays important roles in multiple aspects of RNA regulation. m(6)A is installed cotranscriptionally by the METTL3/14 complex, but its direct roles in RNA processing remain unclear. Here, we investigate the presence of m(6)A in nascent RNA of mouse embryo...

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Detalles Bibliográficos
Autores principales:	Wei, Guifeng, Almeida, Mafalda, Pintacuda, Greta, Coker, Heather, Bowness, Joseph S., Ule, Jernej, Brockdorff, Neil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327914/ https://www.ncbi.nlm.nih.gov/pubmed/34131006 http://dx.doi.org/10.1101/gr.271635.120

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