N‐glycan processing selects ERAD‐resistant misfolded proteins for ER‐to‐lysosome‐associated degradation

Efficient degradation of by‐products of protein biogenesis maintains cellular fitness. Strikingly, the major biosynthetic compartment in eukaryotic cells, the endoplasmic reticulum (ER), lacks degradative machineries. Misfolded proteins in the ER are translocated to the cytosol for proteasomal degra...

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Detalles Bibliográficos
Autores principales: Fregno, Ilaria, Fasana, Elisa, Soldà, Tatiana, Galli, Carmela, Molinari, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327951/
https://www.ncbi.nlm.nih.gov/pubmed/34152647
http://dx.doi.org/10.15252/embj.2020107240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8327951/
https://www.ncbi.nlm.nih.gov/pubmed/34152647
http://dx.doi.org/10.15252/embj.2020107240

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