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Structure-Function Relationships of Covalent and Non-Covalent BTK Inhibitors

Low-molecular weight chemical compounds have a longstanding history as drugs. Target specificity and binding efficiency represent major obstacles for small molecules to become clinically relevant. Protein kinases are attractive cellular targets; however, they are challenging because they present one...

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Detalles Bibliográficos
Autores principales: Zain, Rula, Vihinen, Mauno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328433/
https://www.ncbi.nlm.nih.gov/pubmed/34349760
http://dx.doi.org/10.3389/fimmu.2021.694853