Cargando…

Homo-oligomerization of the human adenosine A(2A) receptor is driven by the intrinsically disordered C-terminus

G protein-coupled receptors (GPCRs) have long been shown to exist as oligomers with functional properties distinct from those of the monomeric counterparts, but the driving factors of oligomerization remain relatively unexplored. Herein, we focus on the human adenosine A(2A) receptor (A(2A)R), a mod...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nguyen, Khanh Dinh Quoc, Vigers, Michael, Sefah, Eric, Seppälä, Susanna, Hoover, Jennifer Paige, Schonenbach, Nicole Star, Mertz, Blake, O'Malley, Michelle Ann, Han, Songi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328514/ https://www.ncbi.nlm.nih.gov/pubmed/34269678 http://dx.doi.org/10.7554/eLife.66662

Ejemplares similares

Functional consequences of the oligomeric assembly of Proteorhodopsin
por: Hussain, Sunyia, et al.
Publicado: (2015)

Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase
por: Karandur, Deepti, et al.
Publicado: (2020)

Autophagosome membrane expansion is mediated by the N-terminus and cis-membrane association of human ATG8s
por: Zhang, Wenxin, et al.
Publicado: (2023)

Structural diversity of oligomeric β-propellers with different numbers of identical blades
por: Afanasieva, Evgenia, et al.
Publicado: (2019)

Dissecting the phase separation and oligomerization activities of the carboxysome positioning protein McdB
por: Basalla, Joseph L, et al.
Publicado: (2023)

Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction
por: Anderson, Brent W, et al.
Publicado: (2019)

GPCR homo-oligomerization
por: Milligan, Graeme, et al.
Publicado: (2019)

Cryo-EM structure of the adenosine A(2A) receptor coupled to an engineered heterotrimeric G protein
por: García-Nafría, Javier, et al.
Publicado: (2018)

A non-redundant dataset of inter-residue lysine-lysine solvent accessible surface distances in homo-oligomeric protein complexes
por: Gaber, Aljaž
Publicado: (2019)

Plant-exuded chemical signals induce surface attachment of the bacterial pathogen Pseudomonas syringae
por: O’Malley, Megan R., et al.
Publicado: (2023)

Biochemical Characterization of Two Clinically-Relevant Human Fumarase Variants Defective for Oligomerization
por: Bulku, Artemisa, et al.
Publicado: (2018)

Phosphorylation of the N-terminus of Syntaxin-16 controls interaction with mVps45 and GLUT4 trafficking in adipocytes
por: Bremner, Shaun K., et al.
Publicado: (2023)

De novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition
por: Stefan, Erich, et al.
Publicado: (2021)

Acetylation of N-terminus and two internal amino acids is dispensable for degradation of a protein that aberrantly engages the endoplasmic reticulum translocon
por: Engle, Sarah M., et al.
Publicado: (2017)

Oligomerization of p62 allows for selection of ubiquitinated cargo and isolation membrane during selective autophagy
por: Wurzer, Bettina, et al.
Publicado: (2015)

A proposal for clinical trials of COVID-19 treatment using homo-harringtonine
por: Wen, Hai-Jun, et al.
Publicado: (2020)

The Shu complex prevents mutagenesis and cytotoxicity of single-strand specific alkylation lesions
por: Bonilla, Braulio, et al.
Publicado: (2021)

Quantitative mapping of protein-peptide affinity landscapes using spectrally encoded beads
por: Nguyen, Huy Quoc, et al.
Publicado: (2019)

A terpene synthase-cytochrome P450 cluster in Dictyostelium discoideum produces a novel trisnorsesquiterpene
por: Chen, Xinlu, et al.
Publicado: (2019)

Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets
por: Schirle, Nicole T, et al.
Publicado: (2015)

Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness
por: Tye, Blake W, et al.
Publicado: (2019)

Adenosine diphosphate restricts the protein remodeling activity of the Hsp104 chaperone to Hsp70 assisted disaggregation
por: Kłosowska, Agnieszka, et al.
Publicado: (2016)

Collateral deletion of the mitochondrial AAA+ ATPase ATAD1 sensitizes cancer cells to proteasome dysfunction
por: Winter, Jacob M, et al.
Publicado: (2022)

Addition of L-cysteine to the N- or C-terminus of the all-D-enantiomer [(D)(KLAKLAK)(2)] increases antimicrobial activities against multidrug-resistant Pseudomonas aeruginosa, Acinetobacter baumannii and Escherichia coli
por: Ohno, Maki K., et al.
Publicado: (2020)

N-terminus oligomerization is conserved in intracellular calcium release channels
por: Zissimopoulos, Spyros, et al.
Publicado: (2014)

Evolution of homo‐oligomerization of methionine S‐adenosyltransferases is replete with structure–function constrains
por: Kleiner, Daniel, et al.
Publicado: (2022)

Design of Diverse Asymmetric Pockets in De Novo Homo-oligomeric Proteins
por: Gerben, Stacey R, et al.
Publicado: (2023)

EpCAM homo-oligomerization is not the basis for its role in cell-cell adhesion
por: Gaber, Aljaž, et al.
Publicado: (2018)

CX3CL1 homo-oligomerization drives cell-to-cell adherence
por: Ostuni, Mariano A., et al.
Publicado: (2020)

Modeling and Structure Determination of Homo-Oligomeric Proteins: An Overview of Challenges and Current Approaches
por: Gaber, Aljaž, et al.
Publicado: (2021)

Identification of NLRP3(PYD) Homo-Oligomerization Inhibitors with Anti-Inflammatory Activity
por: Moasses Ghafary, Soroush, et al.
Publicado: (2022)

Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing
por: Zhang, Li, et al.
Publicado: (2015)

Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice
por: Overman, Jeroen, et al.
Publicado: (2017)

Structural basis for the recognition of spliceosomal SmN/B/B’ proteins by the RBM5 OCRE domain in splicing regulation
por: Mourão, André, et al.
Publicado: (2016)

The gating cycle of a K(+) channel at atomic resolution
por: Cuello, Luis G, et al.
Publicado: (2017)

CK1/Doubletime activity delays transcription activation in the circadian clock
por: Top, Deniz, et al.
Publicado: (2018)

In vitro FRET analysis of IRE1 and BiP association and dissociation upon endoplasmic reticulum stress
por: Kopp, Megan C, et al.
Publicado: (2018)

eIF1A residues implicated in cancer stabilize translation preinitiation complexes and favor suboptimal initiation sites in yeast
por: Martin-Marcos, Pilar, et al.
Publicado: (2017)

Molecular mechanism to target the endosomal Mon1-Ccz1 GEF complex to the pre-autophagosomal structure
por: Gao, Jieqiong, et al.
Publicado: (2018)

Gene network analysis identifies a central post-transcriptional regulator of cellular stress survival
por: Tien, Matthew, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_48qbcrvjlho3ng8rqnjl8rgee1