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Calmodulin Antagonist W-7 Enhances Intermediate Conductance Ca(2+)- Sensitive Basolateral Potassium Channel (IK(Ca)) Activity in Human Colonic Crypts

Intermediate conductance potassium (IK(Ca)) channels are exquisitively Ca(2+) sensitive, intracellular Ca(2+) regulating channel activity by complexing with calmodulin (CaM), which is bound to the cytosolic carboxyl tail. Although CaM antagonists might be expected to decrease IK(Ca) channel activity...

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Detalles Bibliográficos
Autores principales: Bowley, Kate A., Sandle, Geoffrey I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328907/
https://www.ncbi.nlm.nih.gov/pubmed/34313792
http://dx.doi.org/10.1007/s00232-021-00193-y