Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease

Impaired cellular cholesterol efflux is a key factor in the progression of renal, cardiovascular, and autoimmune diseases. Here we describe a class of 5-arylnicotinamide compounds, identified through phenotypic drug discovery, that upregulate ABCA1-dependent cholesterol efflux by targeting Oxysterol...

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Detalles Bibliográficos
Autores principales: Wright, Matthew B., Varona Santos, Javier, Kemmer, Christian, Maugeais, Cyrille, Carralot, Jean-Philippe, Roever, Stephan, Molina, Judith, Ducasa, G. Michelle, Mitrofanova, Alla, Sloan, Alexis, Ahmad, Anis, Pedigo, Christopher, Ge, Mengyuan, Pressly, Jeffrey, Barisoni, Laura, Mendez, Armando, Sgrignani, Jacopo, Cavalli, Andrea, Merscher, Sandra, Prunotto, Marco, Fornoni, Alessia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329197/
https://www.ncbi.nlm.nih.gov/pubmed/34341345
http://dx.doi.org/10.1038/s41467-021-24890-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329197/
https://www.ncbi.nlm.nih.gov/pubmed/34341345
http://dx.doi.org/10.1038/s41467-021-24890-3

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