Cargando…

Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease

Impaired cellular cholesterol efflux is a key factor in the progression of renal, cardiovascular, and autoimmune diseases. Here we describe a class of 5-arylnicotinamide compounds, identified through phenotypic drug discovery, that upregulate ABCA1-dependent cholesterol efflux by targeting Oxysterol...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wright, Matthew B., Varona Santos, Javier, Kemmer, Christian, Maugeais, Cyrille, Carralot, Jean-Philippe, Roever, Stephan, Molina, Judith, Ducasa, G. Michelle, Mitrofanova, Alla, Sloan, Alexis, Ahmad, Anis, Pedigo, Christopher, Ge, Mengyuan, Pressly, Jeffrey, Barisoni, Laura, Mendez, Armando, Sgrignani, Jacopo, Cavalli, Andrea, Merscher, Sandra, Prunotto, Marco, Fornoni, Alessia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329197/ https://www.ncbi.nlm.nih.gov/pubmed/34341345 http://dx.doi.org/10.1038/s41467-021-24890-3

Ejemplares similares

ABCA1 deficiency contributes to podocyte pyroptosis priming via the APE1/IRF1 axis in diabetic kidney disease
por: Ito, Marie, et al.
Publicado: (2023)

New insights into renal lipid dysmetabolism in diabetic kidney disease
por: Mitrofanova, Alla, et al.
Publicado: (2021)

SMPDL3b modulates insulin receptor signaling in diabetic kidney disease
por: Mitrofanova, A., et al.
Publicado: (2019)

Mitochondrial Contribution to Inflammation in Diabetic Kidney Disease
por: Mitrofanova, Alla, et al.
Publicado: (2022)

Implications of Sphingolipid Metabolites in Kidney Diseases
por: Mallela, Shamroop kumar, et al.
Publicado: (2022)

Role of Sphingolipid Signaling in Glomerular Diseases: Focus on DKD and FSGS
por: Mitrofanova, Alla, et al.
Publicado: (2020)

Sphingomyelin phosphodiesterase acid like 3B (SMPDL3b) regulates Perilipin5 (PLIN5) expression and mediates lipid droplet formation
por: Mallela, Shamroop Kumar, et al.
Publicado: (2022)

Glucose- and Non-Glucose-Induced Mitochondrial Dysfunction in Diabetic Kidney Disease
por: Ito, Marie, et al.
Publicado: (2022)

Use of Lipid-Modifying Agents for the Treatment of Glomerular Diseases
por: Ge, Mengyuan, et al.
Publicado: (2021)

Empagliflozin reduces podocyte lipotoxicity in experimental Alport syndrome
por: Ge, Mengyuan, et al.
Publicado: (2023)

Discoidin domain receptor 1 activation links extracellular matrix to podocyte lipotoxicity in Alport syndrome
por: Kim, Jin-Ju, et al.
Publicado: (2020)

The Vicious Cycle of Renal Lipotoxicity and Mitochondrial Dysfunction
por: Ge, Mengyuan, et al.
Publicado: (2020)

Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration
por: Storti, Federica, et al.
Publicado: (2019)

Cyclodextrin Protects Podocytes in Diabetic Kidney Disease
por: Merscher-Gomez, Sandra, et al.
Publicado: (2013)

Podocyte Pathology and Nephropathy – Sphingolipids in Glomerular Diseases
por: Merscher, Sandra, et al.
Publicado: (2014)

Metabolism, Energetics, and Lipid Biology in the Podocyte – Cellular Cholesterol-Mediated Glomerular Injury
por: Merscher, Sandra, et al.
Publicado: (2014)

In Vivo Inflammation Does Not Impair ABCA1-Mediated Cholesterol Efflux Capacity of HDL
por: Franssen, Remco, et al.
Publicado: (2012)

The podocyte: glomerular sentinel at the crossroads of innate and adaptive immunity
por: Burke, George W., et al.
Publicado: (2023)

Potential Prognostic Biomarkers of OSBPL Family Genes in Patients with Pancreatic Ductal Adenocarcinoma
por: Chou, Cheng-Wei, et al.
Publicado: (2021)

OSBPL2 Is Required for the Binding of COPB1 to ATGL and the Regulation of Lipid Droplet Lipolysis
por: Wang, Tianming, et al.
Publicado: (2020)

Epigenetics of Skeletal Muscle-Associated Genes in the ASB, LRRC, TMEM, and OSBPL Gene Families
por: Ehrlich, Kenneth C., et al.
Publicado: (2020)

OSBPL2 mutations impair autophagy and lead to hearing loss, potentially remedied by rapamycin
por: Koh, Young Ik, et al.
Publicado: (2022)

The expression, immune infiltration, prognosis, and experimental validation of OSBPL family genes in liver cancer
por: Tian, Kunpeng, et al.
Publicado: (2023)

Integrated bioinformatics analysis reveals the function and prognostic value of OSBPL3 in hepatocellular carcinoma
por: Su, Yuanshuai, et al.
Publicado: (2023)

Structural properties of apolipoprotein A-I mimetic peptides that promote ABCA1-dependent cholesterol efflux
por: Islam, Rafique M., et al.
Publicado: (2018)

Piperine inhibits ABCA1 degradation and promotes cholesterol efflux from THP‐1‐derived macrophages
por: Wang, Limei, et al.
Publicado: (2016)

THU490 Role Of Cholesterol Efflux Pump ABCA1 In Macrophages And Subsequent Modulation Of The Tumor Microenvironment
por: Bendre, Shruti V, et al.
Publicado: (2023)

Relationships among Non-Neoplastic Histopathological Features, Kidney Function, Proteinuria, and Other Clinical Factors in Patients Undergoing Nephrectomy
por: Aponte Becerra, Laura, et al.
Publicado: (2023)

Independent Effects of Kidney Function and Cholesterol Efflux on Cardiovascular Mortality
por: Ritsch, Andreas, et al.
Publicado: (2022)

Quercetin enhances ABCA1 expression and cholesterol efflux through a p38-dependent pathway in macrophages
por: Chang, Yu-Cheng, et al.
Publicado: (2012)

Novel interactomics approach identifies ABCA1 as direct target of evodiamine, which increases macrophage cholesterol efflux
por: Wang, Limei, et al.
Publicado: (2018)

Liraglutide improves lipid metabolism by enhancing cholesterol efflux associated with ABCA1 and ERK1/2 pathway
por: Wu, Ya-Ru, et al.
Publicado: (2019)

Mangiferin promotes macrophage cholesterol efflux and protects against atherosclerosis by augmenting the expression of ABCA1 and ABCG1
por: Ren, Kun, et al.
Publicado: (2019)

Rosmarinic Acid Increases Macrophage Cholesterol Efflux through Regulation of ABCA1 and ABCG1 in Different Mechanisms
por: Nyandwi, Jean-Baptiste, et al.
Publicado: (2021)

Flipped C-Terminal Ends of APOA1 Promote ABCA1-dependent Cholesterol Efflux by Small HDLs
por: He, Yi, et al.
Publicado: (2023)

Adenine crosses the biomarker bridge: from ‘omics to treatment in diabetic kidney disease
por: Drexler, Yelena, et al.
Publicado: (2023)

Clinical Value and Potential Mechanisms of Oxysterol-Binding Protein Like 3 (OSBPL3) in Human Tumors
por: Hao, Na, et al.
Publicado: (2021)

The relationships of OSBPL3 expression with KI-67 expression and KRAS mutations in CRC: implications for diagnosis and prognosis
por: Zhang, Min, et al.
Publicado: (2022)

Prognostic and biological function value of OSBPL3 in colorectal cancer analyzed by multi-omic data analysis
por: Wang, Chengxing, et al.
Publicado: (2023)

ABCA1‐Mediated Cholesterol Efflux Capacity to Cerebrospinal Fluid Is Reduced in Patients With Mild Cognitive Impairment and Alzheimer's Disease
por: Yassine, Hussein N., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_kdmt3hk0dnr1uer4c2ngifbiul