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SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation

Excessive inflammatory responses induced upon SARS-CoV-2 infection are associated with severe symptoms of COVID-19. Inflammasomes activated in response to SARS-CoV-2 infection are also associated with COVID-19 severity. Here, we show a distinct mechanism by which SARS-CoV-2 N protein promotes NLRP3...

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Detalles Bibliográficos
Autores principales: Pan, Pan, Shen, Miaomiao, Yu, Zhenyang, Ge, Weiwei, Chen, Keli, Tian, Mingfu, Xiao, Feng, Wang, Zhenwei, Wang, Jun, Jia, Yaling, Wang, Wenbiao, Wan, Pin, Zhang, Jing, Chen, Weijie, Lei, Zhiwei, Chen, Xin, Luo, Zhen, Zhang, Qiwei, Xu, Meng, Li, Geng, Li, Yongkui, Wu, Jianguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329225/
https://www.ncbi.nlm.nih.gov/pubmed/34341353
http://dx.doi.org/10.1038/s41467-021-25015-6