Implication of specific retinal cell-type involvement and gene expression changes in AMD progression using integrative analysis of single-cell and bulk RNA-seq profiling

Age‐related macular degeneration (AMD) is a blinding eye disease with no unifying theme for its etiology. We used single-cell RNA sequencing to analyze the transcriptomes of ~ 93,000 cells from the macula and peripheral retina from two adult human donors and bulk RNA sequencing from fifteen adult hu...

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Detalles Bibliográficos
Autores principales: Lyu, Yafei, Zauhar, Randy, Dana, Nicholas, Strang, Christianne E., Hu, Jian, Wang, Kui, Liu, Shanrun, Pan, Naifei, Gamlin, Paul, Kimble, James A., Messinger, Jeffrey D., Curcio, Christine A., Stambolian, Dwight, Li, Mingyao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329233/
https://www.ncbi.nlm.nih.gov/pubmed/34341398
http://dx.doi.org/10.1038/s41598-021-95122-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329233/
https://www.ncbi.nlm.nih.gov/pubmed/34341398
http://dx.doi.org/10.1038/s41598-021-95122-3

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