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X-ray crystallography reveals molecular recognition mechanism for sugar binding in a melibiose transporter MelB

Major facilitator superfamily_2 transporters are widely found from bacteria to mammals. The melibiose transporter MelB, which catalyzes melibiose symport with either Na(+), Li(+), or H(+), is a prototype of the Na(+)-coupled MFS transporters, but its sugar recognition mechanism has been a long-unsol...

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Detalles Bibliográficos
Autores principales: Guan, Lan, Hariharan, Parameswaran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329300/
https://www.ncbi.nlm.nih.gov/pubmed/34341464
http://dx.doi.org/10.1038/s42003-021-02462-x