Cargando…
Combining SARS-CoV-2 Proofreading Exonuclease and RNA-Dependent RNA Polymerase Inhibitors as a Strategy to Combat COVID-19: A High-Throughput in silico Screening
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions of people worldwide. Currently, many clinical trials in search of effective COVID-19 drugs are underway. Viral RNA-dependent RNA polymerase (RdRp) remains the target of choice for prophylactic or curative treatment of...
Autores principales: | Khater, Shradha, Kumar, Pawan, Dasgupta, Nandini, Das, Gautam, Ray, Shashikant, Prakash, Amresh |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329495/ https://www.ncbi.nlm.nih.gov/pubmed/34354677 http://dx.doi.org/10.3389/fmicb.2021.647693 |
Ejemplares similares
-
Proofreading exonuclease activity of human DNA polymerase δ and its effects on lesion-bypass DNA synthesis
por: Fazlieva, Ruzaliya, et al.
Publicado: (2009) -
The dominant role of proofreading exonuclease activity of replicative polymerase ε in cellular tolerance to cytarabine (Ara-C)
por: Tsuda, Masataka, et al.
Publicado: (2017) -
The proofreading exonuclease subunit ε of Escherichia coli DNA polymerase III is tethered to the polymerase subunit α via a flexible linker
por: Ozawa, Kiyoshi, et al.
Publicado: (2008) -
The exceptionally high rate of spontaneous mutations in the polymerase delta proofreading exonuclease-deficient Saccharomyces cerevisiae strain starved for adenine
por: Achilli, Alessandro, et al.
Publicado: (2004) -
The 3′–5′ proofreading exonuclease of archaeal family-B DNA polymerase hinders the copying of template strand deaminated bases
por: Russell, Henry J., et al.
Publicado: (2009)