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Stage-specific transcriptomic changes in pancreatic α-cells after massive β-cell loss
BACKGROUND: Loss of pancreatic insulin-secreting β-cells due to metabolic or autoimmune damage leads to the development of diabetes. The discovery that α-cells can be efficiently reprogrammed into insulin-secreting cells in mice and humans has opened promising avenues for innovative diabetes therapi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330016/ https://www.ncbi.nlm.nih.gov/pubmed/34340653 http://dx.doi.org/10.1186/s12864-021-07812-x |